POSTED June 14, 2016
Postdoctoral Research Scientist – Molecular Pathology
Centre for Cancer Research
Closing 5pm, Thursday 7 July 2016
The Westmead Institute for Medical Research (WIMR) is one of the largest medical research institutes in Australia conducting research into a wide range of important human disorders affecting both adults and children. Our research spans infectious and immune diseases; cancer and leukaemia; liver and metabolic diseases; eye and brain related disorders and heart and respiratory disorders. Our bench to bedside philosophy ensures patients benefit from our latest research discoveries. WIMR is proudly affiliated with The University of Sydney and Westmead Hospital.
The Gynaecological Oncology Research Group within the Centre for Cancer Research aims to better target treatment to individual patients through understanding the molecular drivers of treatment response in ovarian cancer. With researchers forming an integral part of the multidisciplinary team caring for women with gynaecological cancers at Westmead Hospital, research conducted by the group is well-positioned to be quickly translated into new tests and treatments that are of direct benefit to patients.
The group is seeking a Postdoctoral Research Scientist in the field of Molecular Pathology to provide molecular and genomic expertise to a new Translational Research Program. The position will be part of a collaborative team working to integrate genomic pathology into the multidisciplinary team based model of care for ovarian cancer.
This is a full-time, 3 year contract position.
- Developing clinical quality accredited molecular assays.
- Mutation variant reporting and analysis of other somatic alterations that contribute to ovarian cancer pathogenesis and response to treatment, including gene copy number and gene expression variations, within a team environment.
- Integration of analysis methods and interpretation of data from a range of molecular assay platforms.
- Implementation of bioinformatics pipelines for the analysis of molecular data.
- Working with collaborators within the Institute of Clinical Pathology and Medical Research and Pathology West to implement new molecular assays into routine clinical practice within the health care system.
- Contribute to the research activities of the Gynaecological Oncology Research Group as directed by the Head.
- Collect and coordinate data requirements for research projects, grant applications and publications as directed by the Head of the Gynaecological Oncology Research Group.
POSTED June 10, 2016
PostDoc in Systems Biology / Personalized Medicine
Closing 5pm, Friday 29 July 2016
Salary: $93,182 – $103,664
- Passion for improving children’s health*
- Independent role*
- 12 months fixed term with a strong possibility of extension*
The Telethon Kids Institute is one of the nation’s leading medical research organisations with impressive facilities in Subiaco, Western Australia. It is home to more than 700 staff and post-graduate students who are dedicated to tackling the major causes of childhood disease, disability and disadvantage. Our research teams are among the world’s best and we have strong affiliations with Princess Margaret Hospital for Children and all the major Western Australian universities, particularly The University of Western Australia and Curtin University. 2017 will be a significant year for the Telethon Kids Institute with a move to brand new premises within the new children’s hospital building at the QEII Campus in Nedlands. The new building will see the Telethon Kids Institute co-located with the new Perth Children’s Hospital and housed in state-of-the-art premises with increased space and improved access to leading-edge technology and research facilities.
The laboratories of Dr Timo Lassmann, Dr Anthony Bosco and Dr Joost Lesterhuis have a joint opening for a postdoctoral position in systems biology. The position is part of a larger effort to establish a competitive personalised medicine program at the Telethon Kids Institute. The postdoc will be involved in creating and applying state of the art computational approaches for network inference to clinical problems. A strong focus will be on integrating secondary functional and other omics measurements with gene regulatory networks to identify key genes and biomarkers relevant to an individual’s disease onset and progression. The work will lead to the creation of a clinical pipeline utilising omics approaches to improve patients’ wellbeing. There are three complementary streams involved in the project in the first instance:
- Towards personalised medicine: the candidate will develop approaches utilising large scale functional datasets from the Encyclopedia of DNA Elements (ENCODE), the Functional Annotation Of Mammalian genome (FANTOM) and the Roadmap Epigenomics project to construct cell type specific gene networks.These will be used to link the variome of patients to the observed disease phenotypes.
- Projecting experimental data derived from genomic studies of pathological conditions in humans and in animal models onto cell type specific gene regulatory networks, and pinpointing actionable possibilities for therapeutic intervention.
- Identification of ‘druggable’ key drivers of cancer-related cellular phenotypes: integration of transcriptomics epigenomics, proteomics and metabolomics data, which will be derived from stateof- the art animal models, as well as samples from patients. This will provide a robust analysis for identifying candidate targets and drugs that can enter a trajectory of clinical translation and commercialisation.
The position represents an exciting opportunity to work at the crossroads between basic science and clinical practise. The successful candidate will have the unique opportunity to be part of a truly interdisciplinary team composed of molecular biologists, statisticians, computational biologists and clinicians.
The successful candidate should have:
- A PhD in a relevant subject area (e.g Computational Biology, Computer Science, Statistics or Mathematics) and a background in programming and command line UNIX/ Linux
- Experience in biological network inference or related work is a bonus
- At least two first author publications in reputed journals and demonstrated their ability to work well in a team. We expect all our lab members to be strongly self motivated and ambitious
The Institute is located in Perth, Western Australia ranked by the economist intelligence unit’s (EIU) as the 9th most liveable city in the world. An exciting new building project will see Telethon Kids researchers moving into a new building co-located with the new Perth Children’s Hospital in 2017. The new state-of-the-art premises will give access to leading-edge technology, research facilities as well as increase interactions with the most innovative and progressive child health clinicians.
How to Apply:
Applicants should read the Job description available here.
Submit your application along with a covering letter to firstname.lastname@example.org. Please quote the position title in the subject heading of your email application.
For further information about this position please contact: Timo.Lassmann@telethonkids.org.au
POSTED March 9th, 2016
Senior Genomic Informatician (Bioinformatics & Genomics)
Work type: Full time
Location: Adelaide CBD
Categories: IT, Pathology
SA Health – Central Adelaide Local Health Network – SA Pathology – Genetics and Molecular Pathology – (Bioinformatics & Genomics)
Full time, Ongoing – $106,563 – $116,401- PO4
Working with an enthusiastic team of clinical, scientific and technical staff in the exciting and expanding area of clinical genomics, this is a great opportunity to improve the health and wellbeing of South Australians. The incumbent will work in diagnostic and clinical translational genomics to improve diagnoses of genetic diseases including inherited genetic disorders and cancer. Our laboratory has strong clinical partnerships to spearhead clinical implementation of genomics and has recently received national accreditation for whole-exome sequencing for diagnostic applications.
The Senior Genome Informatician oversees the delivery of bioinformatics analysis and software solutions for high-throughput genetic testing by applying high level technical expertise to implement and maintain genome analysis pipelines for diagnostic application. Working collaboratively with Unit Heads and service development scientists, the Senior Genome Informatician will determine the most efficient way to deliver bioinformatics and genome analysis pipelines to meet service requirements for genetic diagnoses.
The Senior Genome Informatician contributes to defining best-practise standards for bioinformatics and genomic analysis in the Directorate and contributes to national and international genomic initiatives to advance clinical genomics. The incumbent will participate in research activities, including research publications and applications for funding, as appropriate.
Appointment will be subject to a satisfactory Criminal History Check.
POSTED June 22nd, 2015
PhD OPPORTUNITIES IN ADVANCED SHRIMP BREEDING
ARC Industrial Transformation Research Hubs (ITRH) for Advanced Prawn Breeding
Project 1 – Development of genomic resources and unravelling the genetic architecture of complex phenotypic traits in the black tiger prawn (James Cook University & University of Sydney)
Project 2 – Physiological responses to environmental stressors in the black tiger prawn (James Cook University and CSIRO)
Project 3 – Towards genomic selection in the black tiger prawn (University of Sydney)
Project 4 – Genetic diversity of commercial black tiger prawns and evidence for selection signatures (University of Sydney & James Cook University)
Project 5 – Functional transcriptomics of viral infection in the black tiger prawn (James Cook University and CSIRO)
Project 6 - Comparative, evolutionary and functional genomics of the black tiger prawn (University of Sydney & James Cook University)
Project 7 - Genotype by environment under commercial scenarios on performance of black tiger prawn genotypes (University of Sydney and James Cook University)
Project descriptions can be found here
For further details on projects and information on how to apply please contact Professor Dean Jerry, Director ARC Hub for Advanced Prawn Breeding, Townsville, Australia, email: email@example.com
POSTED June 22nd, 2015
GENOME INFORMATICIAN - TECHNOLOGY ADVANCEMENT UNIT - SA Pathology, Adelaide
We are seeking a genome informatician/bioinformatician to work within the Technology Advancement Unit,
Genetic and Molecular Pathology Directorate, on the implementation of diagnostic NGS testing.
This position is based at the Frome Road Laboratories of SA Pathology and it is a permanent full time position.
For further information, see http://jobs.sahealthcareers.com.au/caw/en/job/566243/genome-informatician
Applications close: Cen. Australia Standard Time
POSTED May 25th, 2015
RESEARCH FELLOW – LEUKAEMIA UNIT – UNI. SOUTH AUSTRALIA (Adelaide)
POST-DOCTORAL RESEARCH FELLOW IN LEUKAEMIA - University South Australia, based at the Centre for Cancer Biology (jointly headed by Professors Angel Lopez and Sharad Kumar); 16 month fixed-term contract. For further information, click here
Applications close: 9.00am Tuesday 9 June 2015 ACDT
POSTDOCTORAL RESEARCH FELLOW POSITIONS – UNI. WESTERN AUSTRALIA
Position 1: POST-DOCTORAL RESEARCH FELLOW IN BRAIN EPIGENOMICS - Epigenetics and Genomics Laboratory (Lister Lab); 3 Year appointment. University Western Australia. For further information, click here
Position 2: POST-DOCTORAL RESEARCH FELLOW IN EPIGENOME ENGINEERING - Epigenetics and Genomics Laboratory (Lister Lab); 3 Year appointment. University Western Australia. For further information, click here
Position 3: POST-DOCTORAL RESEARCH FELLOW IN GENOME BIOINFORMATICS - Epigenetics and Genomics Laboratory (Lister Lab); 3 Year appointment. University Western Australia. For further information, click here